报告题目：Extracellular matrix of secondary lymphoid organs impacts on the B-cell fate in the marginal zone and germinal center

报告人：宋健，德国美因茨大学医学院和明斯特大学医学院博士后

主持人：郑彪   教授
报告时间：6月25日 9:30
报告地点：闵行生科院534报告厅
报告人简介：1997年毕业于首都医科大学全科医学专业，2001年获首都医科大学分子生物学硕士学位，2007年获德国科隆大学分子医学博士学位，2007年至今在德国美因茨大学医学院和明斯特大学医学院做博士后研究，主要兴趣在于研究微解剖环境对Ｂ细胞分化和存活的作用及血管外基质对免疫细胞迁移的影响。

报告摘要：Conventional B cell compartment comprise marginal zone (MZ) B cells, and follicular (FO) B cells. Both of them reside in a defined microanatomical anlage that is critical for their distinct functions. MZ B cells that situated in a site of high blood flow, operate as the innate-like lymphocytes by quickly producing antibodies against the T-independent antigen from the circulation. FO B cells, the major B cells population, located adjacent to T cell zone in secondary lymphoid organs and react to the T-dependent antigen. The activated B cells then move into B cell follicles and establish the germinal center (GC), where cells obtain the affinity maturation and become memory B cells or plasma cells. We describe here that an extracellular matrix molecule, laminin 5, which is enriched in the basement membranes of the sinus lining endothelium of MZ and FO, has impacts on both MZ B cell and germinal center B cell.