报告题目：SCF ligase complexes regulate modular elements of molecular machines

报告人：Dr.Michele Pagano. Investigator of Howard Hughes Medical Institute

主持人： 李晓涛   教授

报告时间：5月21日 14:00

报告地点：闵行生科院534报告厅

报告人简介：Michele Pagano, M.D. Investigator of Howard Hughes Medical Institute. Dr. Pagano is also May Ellen and Gerald Jay Ritter Professor of Oncology and a professor of pathology in the NYU Cancer Institute and the Department of Pathology at the New York University School of Medicine. Dr. Pagano explores the roles that the ubiquitin system plays in fundamental cellular processes, such as cell growth, proliferation, and the DNA damage response. His group is also committed to understanding how the deregulation of this regulatory network contributes to malignant transformation. Dr. Michele Pagano has published more than 20 CNS (Cell, Nature, Science) papers in the past 20 years.

报告摘要：Michele Pagano’s group has studied the ubiquitylating enzymes that control proliferation of mammalian cells for more than 15 years. In particular,they focus on SCF (Skp1-Cul1-F-box protein) ubiquitin ligase complexes and the APC/C (an SCF-like ligase).They have played a central role in elucidating the molecular and cellular mechanisms by which SCF ubiquitin ligase complexes control the degradation of twenty-four biologically-significant substrates that monitor and regulate multiple cellular pathways.